About NucleoPhi

Scientific Consulting in Molecular Modeling & Advanced Data Analysis

NucleoPhi applies physics-based molecular simulation, quantum chemistry, and data-driven modeling to solve complex problems, delivering reproducible, decision-ready insights that accelerate research and innovation.

Team Members

Bridging Boundaries: Pioneers in Scientific Computation

We integrate molecular dynamics, quantum chemistry, and advanced data analysis to provide reproducible, decision-ready solutions across biotechnology, drug discovery, and advanced materials.

Mechanism Decoded: High-Impact Molecular Insights

Our rigorously validated research integrates cutting-edge simulation (MD, QM) with experimental data (Spectroscopy, MS) to unlock atomic-level mechanisms, thereby accelerating research and delivering decision-ready solutions in drug and material design.

Structural heterogeneity in the pre-amyloid oligomers of β2-microglobulin

Tyler M. Marcinko, Chungwen Liang, Sergey Savinov, Jianhen Chen, and Richard W. Vachet. J. Mol. Bio 432:396-409 (2019)
Published Papers

A Generalized Framework for Developing Dihedral Torsion Energy Terms in Nucleic Acids Force Fields

Chungwen Liang, David Pekker, Alessio Valentini, and Swagatam Mukhopadhyay. J. Chem. Theory Comput. 21:7535–7549 (2025)
Published Papers

Free Volume Element Sizes and Dynamics in Polystyrene and Poly(methyl methacrylate) Measured with Ultrafast Infrared Spectroscopy

Sebastian M. Fica-Contreras, David J. Hoffman, Junkun Pan, Chungwen Liang, and Michael Fayer. J. Am. Chem. Soc. 143:3583–3594 (2021)
Published Papers

Modulation of Amyloid-β42 Conformation by Small Molecules Through Nonspecific Binding

Chungwen Liang, Sergey N. Savinov, Jasna Fejzo, Stephen J. Eyles, and Jianhan Chen. J. Chem. Theory Comput. 15:5169–5174 (2019)
Published Papers

Revealing the Solvation Structure and Dynamics of Carbonate Electrolytes in Lithium-Ion Batteries by Two-Dimensional Infrared Spectrum Modeling

Chungwen Liang, Kyungwon Kwak, and Minhaeng Cho. J. Phys. Chem. Lett. 8:5779–5784 (2017)
Published Papers

Allocrite sensing and binding by the breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1)

Y. Xu, E. Egido, X. Li-Blatter, R. Müller, G. Merino, S. Bernèche, and A. Seelig. Biochemistry 54, 6195-206 (2015).
Published Papers

Unidirectional Transport Mechanism in an ATP Dependent Exporter

Y. Xu, A. Seelig, S. Bernèche. ACS Central Science. 3:250-258 (2017)
Published Papers

SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1–Nrf2

Anne-Valérie Burgener, and Olivier Bignucolo et. al. Nature Immunology.20:311-1321 (2019)
Published Papers

Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH

Franck C. Chatelain, Nicolas Gilbert, Delphine Bichet, Annaïse Jauch, Sylvain Feliciangeli, Florian Lesage, and Olivier Bignucolo. Nature Communications.15: 3849 (2024)
Published Papers

Autoimmunity and immunodeficiency associated with monoallelic LIG4 mutations via haploinsufficiency

Annaïse J. Jauch, Olivier Bignucolo et. al. Journal of Allergy and Clinical Immunology. 152:500-516 (2023)
Published Papers

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